鐔遍杸鎼滅储锛� 椁�(y菐ng)璞� 椁�(y菐ng)鐗� 闆炶嫍 鍏旇倝 榈濊嫍
鐣滅墽瀹剁缍�(w菐ng)棣栭爜 > 鎶€琛撲腑蹇�> 鍝佺ó绻佽偛 > 鍩哄洜绲勯€插寲鐮旂┒淇冮€叉按绋诲垎瀛愯偛绋敼鑹�
鐣滅墽瀹剁缍�(w菐ng) 渚嗘簮锛氬湅瀹剁鎶€鎴愭灉缍�(w菐ng) 闁辫畝鏁�(sh霉)锛�
銆€銆€姘寸ɑ鐨勮捣婧愪竴鐩存槸鐪惧鐮旂┒鑰呭瓬瀛滆拷姹傜殑鏂姮鍏嬫柉涔嬭瑤銆傛渶杩�锛屼腑鍦嬬瀛稿鍦ㄩ€欏€嬮牁鍩熶腑鍙堟湁浜嗘渶鏂扮殑鐮旂┒鎴愭灉銆�
銆€銆€2011骞�12鏈�11鏃�锛屽湅闅涜憲鍚嶉洔蹇椼€婅嚜鐒剁敓鐗╂妧琛撱€嬶紙NatureBiotechnology锛夊湪绶氱櫦(f膩)琛ㄤ簡涓湅绉戝闄㈡槅鏄庡嫊鐗╃爺绌舵墍绛夋妲嬬殑鐮旂┒浜哄摗鐨勬渶鏂扮爺绌舵垚鏋滐細50鍊嬫按绋诲熀鍥犵祫閲嶆脯搴忓強閬哄偝璁婄暟鏁�(sh霉)鎿�(j霉)搴寤猴紝鐮旂┒绲愭灉鐐烘彮绀哄叐绋牻鍩圭ɑ鐨勮捣婧愰Υ鍖栨鍙叉彁渚涗簡杩勪粖*鏁�(sh霉)鎿�(j霉)閲忕殑鍩哄洜绲勫璀夋摎(j霉)銆�
銆€銆€涓湅绉戝闄㈡槅鏄庡嫊鐗╃爺绌舵墍鐮旂┒鍝＄帇鏂囧拰浠栫殑鐮旂┒鍦橀殜锛岄€氶亷娣卞害娓簭涓€鎵逛唬琛ㄦ€т簽娲查噹鐢熺ɑ鍜屾牻鍩圭ɑ鐨勫熀鍥犵祫锛屾繁搴﹀垎鏋愪簡浜炴床鏍藉煿绋荤殑璧锋簮姝峰彶锛岀祼鏋滄敮鎸佺渤绋诲拰绉堢ɑ鏈夌崹绔嬭捣婧愮殑绲愯珫銆�
銆€銆€鑰屼笖绮崇ɑ寰堝彲鑳介Υ鍖栦簬鎴戝€戦暦姹熶腑涓嬫父鐨勫骞寸敓閲庣敓绋�銆傜帇鏂囧憡瑷淬€婁腑鍦嬬瀛稿牨銆�銆�
銆€銆€姝ら爡鐮旂┒鍦ㄥ叏鐞冭寖鍦嶅収(n猫i)棣栨灏嶆牻鍩圭ɑ鍜岄噹鐢熺ɑ鍩哄洜绲勯€茶澶ц(gu墨)妯＄殑閬哄偝璁婄暟鍒嗘瀽锛岀偤娣卞叆鎸栨帢姘寸ɑ閲嶈杈�(n贸ng)钘濇€х媭鍩哄洜鍙婁績閫叉按绋诲垎瀛愯偛绋敼鑹瓑鐮旂┒鎻愪緵浜嗗璨寸殑鍩哄洜璩囨簮銆�
銆€銆€鎻姘寸ɑ璧锋簮
銆€銆€姘寸ɑ鏄汉椤炴渶鏃╅Υ鍖栫殑浣滅墿涔嬩竴銆傛牻鍩圭ɑ鏈夊叐鍊嬩簽绋�锛岄绮掕純鐭殑绮崇ɑ鍜岄绮掕純闀风殑绉堢ɑ銆傜渤绋讳富瑕佺敓闀峰垎甯冧簬涓湅鍖楅儴銆佹棩鏈�銆侀煋鍦嬬瓑楂樼矾搴﹀湴鍗€(q奴)銆傝€岀绋讳富瑕佺敓闀峰垎甯冨湪涓湅鍗楅儴銆佹澅鍗椾簽銆佸嵃搴︾瓑浣庣矾搴﹀湴鍗€(q奴)銆傚叐绋牻鍩规按绋荤殑璧锋簮鍜屾紨鍖栵紝涓€鐩存槸閫插寲鐢熺墿瀛稿銆佹鍙插瀹跺拰鑰冨彜瀛稿绛夊骞翠締鍔姏姹傜储鐨勫晱椤屻€�
銆€銆€姘寸ɑ鍦ㄥ緸閲庣敓绋婚Υ鍖栧埌鏍藉煿绋荤殑閬庣▼涓�锛屽湪褰㈡厠(t脿i)鍜岀敓鐞嗕笂鐧�(f膩)鐢熶簡宸ㄥぇ鐨勮畩鍖�锛屼絾閫欎竴棣村寲閬庣▼鐨勯伜鍌虫鍒跺拰鍩哄洜绲勯€插寲妯″紡灏氫笉娓呮銆傚悓鏅傜渤绋诲拰绉堢ɑ鐨勮捣婧愬骞翠締涓€鐩村瓨鍦ㄧ埈璀�銆傜帇鏂囧憡瑷淬€婁腑鍦嬬瀛稿牨銆�銆�
銆€銆€鏈夊鑰呰獚鐐�锛屽叐绋椁�(y菐ng)绋绘槸鐛ㄧ珛璧锋簮鐨勩€傚畠鍊戝垎鍒ョ敱涓嶅悓鍦板崁(q奴)鐨勪笉鍚屼汉缇�锛屽湪涓嶅悓鍦伴粸棣村寲鑰屾垚銆傝€屽彟鏈夊鑰呭墖鎸佷笉鍚岃榛�锛屼粬鍊戣獚鐐�锛屽叐绋椁�(y菐ng)绋绘槸涓€娆¤捣婧愮殑锛屽畠鍊戠殑瀛樺湪鍙槸棣村寲鍚庣墿绋仼鎳変笉鍚岀殑鍦扮悊鐠�(hu谩n)澧冪殑绲愭灉銆傚叐娲惧鑰呭悇鎸佽瓑鎿�(j霉)锛屼竴鐩翠互渚嗘湭鏈夊畾璜�銆�
銆€銆€鎿�(j霉)鐜嬫枃浠嬬垂锛屽湪閫欓爡鐮旂┒涓�锛屼粬鍊戦伕鍙栦簡鍏锋湁浠ｈ〃鎬х殑40鍊嬫牻鍩圭ɑ鍝佺郴鍜�10鍊嬩笉鍚屽湴鐞嗕締婧愮殑閲庣敓绋婚€茶浜嗗叏鍩哄洜绲勯噸娓簭鐮旂┒锛屾壘鍒颁簡杩�1500钀€嬪柈鏍歌嫹閰稿鎱�(t脿i)浣嶉粸锛圫NPs锛�锛屽叾涓�650钀偤楂樺彲闈犲害鐨凷NPs锛屼互鍙婁竴澶ф壒鍩哄洜绲勭祼妲嬭畩鐣般€�
銆€銆€鍩轰簬閫欎簺閬哄偝璁婄暟鏁�(sh霉)鎿�(j霉)锛屾垜鍊戞洿鍔犲叏闈㈠湴浜嗚В浜嗘按绋诲叏鍩哄洜绲勭殑閬哄偝璁婄暟鐗瑰緛銆傚悓鏅�锛屽皪绋兢绲愭鍜岀郴绲�(t菕ng)閫插寲鍒嗘瀽绲愭灉涔熻畵鎴戝€戝緸鍏ㄥ熀鍥犳按骞充笂杩芥函浜嗘按绋荤殑棣村寲姝峰彶銆傛垜鍊戠殑鐮旂┒鎴愭灉璀夋槑绉堢ɑ鍜岀渤绋荤殑璧锋簮鐨勭⒑鏄崹绔嬬殑锛岀渤绋诲彲鑳借捣婧愪簬涓湅鏅€氶噹鐢熺ɑ锛岀绋诲墖鍙兘鏄湪鏉卞崡浜炲湴鍗€(q奴)棣村寲鐨�銆傜帇鏂囧憡瑷淬€婁腑鍦嬬瀛稿牨銆嬨€�
銆€銆€鑸囨鍚屾檪锛岀爺绌朵汉鍝＄櫦(f膩)鐝�(xi脿n)浜嗘暩(sh霉)鍗冨€嬭垏浜哄伐閬告搰鐩搁棞鐨勫€欓伕鍩哄洜銆傞€欏氨鍍忔槸绲︽按绋昏偛绋皥瀹跺€戝垪鍑轰竴鍊嬪熀鍥犳竻鍠€傚叾涓湁浜涘熀鍥犺垏姘寸ɑ鐨勮静(n贸ng)钘濇€х媭鍏锋湁閲嶈鐨勭浉闂滄€�锛岃€屽ぇ閮ㄥ垎鍩哄洜鐨勫姛鑳界洰鍓嶉倓涓嶆竻妤�锛屾湁寰呬簬鐮旂┒宸ヤ綔鐨勯€蹭竴姝ュ睍闁�銆傜帇鏂囪锛屾垜鍊戝笇鏈涜兘寰炲熀鍥犵祫姘村钩涓婅В鏋愪笉鍚屾牻鍩瑰拰閲庣敓绋诲熀鍥犵祫搴忓垪鐨勯伜鍌宠畩鐣版儏娉�锛屼互鍒╀簬鍩硅偛楂樼敘(ch菐n)銆佸劒(y艒u)璩�(zh矛)鍜屾姉閫嗙殑姘寸ɑ鏂板搧绋�锛屾彁楂樿偛绋妧琛撳拰姘村钩銆�
銆€銆€寰炴柊鍩哄洜鍒板熀鍥犵祫
銆€銆€浣滅偤棣栧腑绉戝瀹�锛岀帇鏂囩殑閫欓爡鐮旂┒寰楀埌浜�973闋呯洰浜哄伐閬告搰鑸囧熀鍥犵祫閫插寲鐨勬敮鎸併€�
銆€銆€鐜嬫枃鐨勭爺绌剁穵鎵ｅ熀鍥犵殑閫插寲鍜岃捣婧愰€欎竴閲嶅ぇ绉戝鍟忛銆傜稉(j墨ng)閬庡咕骞存帰绱�锛岃彲浜虹瀛稿鐧�(f膩)灞曞嚭浜嗕竴濂楃爺绌舵柊鍩哄洜璧锋簮鍜岄€插寲鐨勯珨绯伙紝灏囧熀鍥犺捣婧愬拰鐧�(f膩)鐢熺殑鐮旂┒鎺ㄥ埌浜嗕竴鍊嬫柊楂樺害銆傝€屾鍓�锛屼笘鐣屼笂鍍呴浂鏄熺煡閬撳咕鍊嬪勾杓曠殑鍩哄洜銆�
銆€銆€閫氶亷绯荤当(t菕ng)鎼滃皨锛岀帇鏂囧拰浠栫殑鍦橀殜宸查憭鍒ュ埌浜嗕竴澶ф壒骞磋紩鍩哄洜锛屽寘鎷尨鐜嬶紙monkeyking锛夊熀鍥犮€佷竴鍊嬪勾杓曠殑RNA鍩哄洜sphinx锛堟柉鑺厠鏂級鍩哄洜銆佷竴鍊嬫帶鍒剁簿瀛愭垚鐔熺殑nsr鍩哄洜鍜屼竴鍊嬪钩琛＄敓娈栬垏澹藉懡鐨凜G11700鍩哄洜銆傞€欎簺骞磋紩鍩哄洜鐨勭櫦(f膩)鐝�(xi脿n)鍜屽姛鑳界爺绌剁偤鍦ㄨ嚜鐒剁墿绋腑鏂伴伜鍌崇祼妲嬬殑璧锋簮閫插寲鎻愪緵浜嗙郴绲�(t菕ng)鐨勯棥閲嬨€�
銆€銆€鑰屽湪鏈締骞惧勾閲�锛屾垜鍊戝皣涓昏鍦嶇篂鍩哄洜绲勪腑鏂板熀鍥犲強鍏舵柊鍔熻兘鐨勮捣婧愰€插寲鍜屽熀鍥犵祫鐨勯€插寲姗熷埗閫茶鐮旂┒銆傜帇鏂囪銆�
銆€銆€鍦ㄧ帇鏂囩湅渚�锛屽椁�(y菐ng)鍕曠墿鍜屾牻鍩逛綔鐗╂槸杈�(n贸ng)妤�(y猫)鐢熺敘(ch菐n)鐨勯噸瑕佺墿璩�(zh矛)鍩虹銆備絾闀锋湡浠ヤ締锛屼汉鍊戝皪浜庝汉宸ラ伕鎿囩殑閬哄偝姗熷埗鍜屽湪浜哄伐閬告搰涓嬪熀鍥犲拰鍩哄洜绲勭殑璁婂寲銆侀€插寲瑕�(gu墨)寰嬩緷鐒剁煡涔嬬敋灏�锛岀敋鑷虫瘮鎴戝€戝皪鑷劧閬告搰姗熷埗鐨勪簡瑙ｉ倓灏戙€�
銆€銆€杩戝勾渚嗛毃钁楀熀鍥犵祫鏁�(sh霉)鎿�(j霉)鐨勫ぇ閲忕⿳绱拰閫插寲鍩哄洜绲勫鐮旂┒鐞嗚珫鍜屾妧琛撶殑鐧�(f膩)灞�锛岀従(xi脿n)鍦ㄤ腑鍦嬬瀛稿宸茬稉(j墨ng)鍙互鍦ㄥ熀鍥犵祫鐨勫ぇ灏哄害姘村钩绯荤当(t菕ng)鐮旂┒浜哄伐閬告搰鐨勯伜鍌充綔鐢ㄦ鍒�銆�
銆€銆€鎴戝€戠殑鐮旂┒姝ｆ槸閫氶亷灏嶉Υ椁�(y菐ng)鐢熺墿鍙婂叾閲庣敓绋熀鍥犵祫姘村钩鐨勫ぇ瑕�(gu墨)妯℃瘮杓冨垎鏋�锛屽畾缇╁彈浜哄伐閬告搰浣滅敤鐨勫ぇ閲忓熀鍥犲拰鍩哄洜绲勫崁(q奴)鍩�锛屾绱嶇附绲愪汉宸ラ伕鎿囦綔鐢ㄧ殑閬哄偝姗熷埗鍜屼竴鑸(gu墨)寰�锛岄憭鍒ュ嚭涓€鎵硅垏浜哄伐閬告搰鎬х媭鐩搁棞鐨勯噸瑕佸熀鍥�锛岀偤閬哄偝鍜屽熀鍥犲伐绋嬭偛绋彁渚涢噸瑕佺殑鐞嗚珫鎸囧皫鍜屽熀鍥犺硣婧愩€傜帇鏂囪锛屾湭渚嗭紝鎴戝€戝皣鎶婂皪姘寸ɑ鍩哄洜绲勭殑鐮旂┒鎺ㄥ唬鍒板叾浠栫墿绋�銆傛瘮濡傝爆鐗涚緤绛夊椁�(y菐ng)鍕曟鐗�锛岄€欏皣鑸囦腑鍦嬫湭渚嗚静(n贸ng)妤�(y猫)鍜岀厂椋熷畨鍏ㄦ伅鎭浉闂�銆�
銆€銆€
鈶犳湰缍�(w菐ng)娉ㄦ槑鈥滅ǹ浠朵締婧愶細鐣滅墽瀹剁缍�(w菐ng)(Agroxq.com)鈥濈殑鎵€鏈夋枃瀛�銆佹暩(sh霉)鎿�(j霉)銆佸湒鐗囧拰闊宠闋荤ǹ浠�锛岀増娆婂潎灞€�鐣滅墽瀹剁缍�(w菐ng)鈥�(Agroxq.com)鎵€鏈�锛屼换浣曚紒妤�(y猫)銆佸獟楂�銆佺恫(w菐ng)绔欐垨鍊嬩汉鏈稉(j墨ng)鏈恫(w菐ng)鍗�(xi茅)璀版巿娆婁笉寰楄綁杓�銆侀張鎺�銆佽綁璨兼垨浠ュ叾浠栨柟寮忓京鍒朵娇鐢�銆傚嚒缍�(j墨ng)鏈恫(w菐ng)鍗�(xi茅)璀版巿娆婏紝鍦ㄤ娇鐢ㄦ檪蹇呴爤娉ㄦ槑鈥滅ǹ浠朵締婧愶細鐣滅墽瀹剁缍�(w菐ng)(Agroxq.com)鈥�锛岄仌鑰呮湰缍�(w菐ng)灏囦緷娉曡拷绌惰铂浠汇€�
鈶℃湰缍�(w菐ng)鏈敞鏄庘€滅ǹ浠朵締婧愶細鐣滅墽瀹剁缍�(w菐ng)(Agroxq.com)鈥濈殑鏂囷紡鍦栫瓑绋夸欢鍧囩偤杞夎級绋�锛屾湰缍�(w菐ng)杞夎級鍑轰簬鍌抽仦鏇村淇℃伅涔嬬洰鐨勶紝骞朵笉鎰忓懗钁楄磰鍚屽叾瑙€榛炴垨璀夊鍏跺収(n猫i)瀹圭殑鐪熷鎬�銆傚鍏朵粬濯掗珨銆佺恫(w菐ng)绔欐垨鍊嬩汉寰炴湰缍�(w菐ng)涓嬭級浣跨敤锛屽繀闋堜繚鐣欐湰缍�(w菐ng)娉ㄦ槑鐨勨€滅ǹ浠朵締婧愨€�锛屽苟鑷矤鐗堟瑠绛夋硶寰嬭铂浠汇€傚鎿呰嚜绡℃敼鐐衡€滅ǹ浠朵締婧愶細鐣滅墽瀹剁缍�(w菐ng)(Agroxq.com)鈥濓紝鏈恫(w菐ng)灏囦緷娉曡拷绌惰铂浠�銆傚灏嶇ǹ浠跺収(n猫i)瀹规湁鐤戣锛岃珛鍙婃檪鑸囨垜鍊戣伅(li谩n)绯�銆�
鈶㈠洜浜掕伅(li谩n)缍�(w菐ng)淇℃伅鐨勫啑闆滄€у強鏇存柊鐨勮繀鐚涙€�锛屾湰缍�(w菐ng)鐒℃硶鍙婃檪鑱�(li谩n)绯诲埌鎵€杞夎級绋夸欢鐨勪綔鑰�锛屽鏈恫(w菐ng)杞夎級绋挎秹鍙婄増娆婄瓑鍟忛锛岃珛鐩搁棞浣滆€呰绋垮悗鍏╁懆鍏�(n猫i)鍙婃檪渚嗛浕鎴栦締鍑借垏鈥�鐣滅墽瀹剁缍�(w菐ng)鈥�(Agroxq.com)鑱�(li谩n)绯�銆�
